Single-cell Profiling in Multiple Myeloma May Improve Diagnosis, Treatment, Study Suggests

Analysis of thousands of individual cells in multiple myeloma patients allows for a much more precise diagnosis — distinguishing asymptomatic, early-stage patients from those with full-blown disease — and may guide treatment choices toward a more personalized approach, a study shows.

The study, “Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma,” was published in Nature Medicine.

Multiple myeloma occurs when the cells that make antibodies — called plasma cells — start dividing out of control, eventually leading to disease. Although there have been significant improvements in treatment in recent years, many therapies still aren’t curative, and most patients relapse.

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