Increased Risk of Myeloma in African Americans Driven By Higher Rates of 3 Disease Subtypes

Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), a precursor to MM, are 2 to 3 times more common in African Americans than European Americans, representing one of the largest racial disparities of all cancer types. According to the results of a study published in Blood Cancer Journal, the increased incidence of MM among people of African descent is driven specifically by the higher frequency of 3 cytogenetic subtypes: t(11;14), t(14;16), and t(14;20).1

The study included 881 samples from patients with monoclonal gammopathy, the majority of whom had been diagnosed with MM. About half the patients were treated at the Mayo Clinic in Minnesota, Florida, or Arizona, and half were seen at other hospitals in the United States.

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