Expert Reflects on “Incredible” Data Seen With bb2121 in Heavily Pretreated Myeloma

The deep and durable phase I responses seen with the anti-BCMA chimeric antigen receptor (CAR) T-cell therapy bb2121 in patients with relapsed/refractory heavily pretreated multiple myeloma have prompted a phase II study, which is currently ongoing, according to Noopur Raje, MD.

Data from the phase I CRB-401 trial showed bb2121 was associated with a 95.5% overall response rate. Moreover, it induced a progression-free survival (PFS) of 11.8 months, with a median duration of response of 10.8 months.

“Given that we are seeing stringent responses in patients who are minimal residual disease (MRD) negative—which we never would have expected to see in a patient population that was as refractory as it was—it’s really encouraging,” said Raje, lead author of the CRB-401 study.

While CAR T-cell therapy has shown promise, there is still a need for treatment that caters to narrower patient populations. Recent data suggest that selinexor, an emerging novel agent, could address this issue. Based on results from the phase IIb STORM trial, a rolling submission of an FDA new drug application was completed for selinexor in August 2018.

In an interview with Targeted Oncology, Raje, director of the Center for Multiple Myeloma at Massachusetts General Hospital Cancer Center, discussed the latest treatment advances in multiple myeloma.

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