A group of “real-world” patients with relapsed or refractory multiple myeloma had high response rates and an overall survival (OS) of about 3 years when treated with bortezomib-based therapy, according to results of the electronic Velcade Observational Study (eVOBs).
The open-label, observational, multicenter study included 873 patients scheduled to receive intravenous bortezomib for relapsed or refractory myeloma. Patients had a median of two lines of therapy prior to initiating bortezomib; 30% of the patients had thalidomide-based treatment, 22% had melphalan-based treatment, and 12% had cyclophosphamide/vincristine/doxorubicin/dexamethasone–based therapy.
Sixty-nine percent of patients responded to treatment, including 37% with a complete or near-complete response. The median time to response was 1.8 months, and the median time to next therapy was 9.7 months. Patients had a median treatment-free interval (TFI) of almost 8 months.
After 22.6 months’ follow-up, the median progression-free survival (PFS) was 12 months and the median OS was 36.1 months.
Read more: http://www.cancernetwork.com/multiple-myeloma/bortezomib-based-therapy-effective-relapsedrefractory-myeloma