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Alexander M. Lesokhin, MD, assistant attending, Department of Medicine and Myeloma Service, Memorial Sloan Kettering Cancer Center, discusses some of the exciting advancements currently happening in the field of multiple myeloma. According to Lesokhin, a lot of the excitement is around chimeric antigen receptor (CAR) T-cells, though they are not FDA approved yet. Data has...
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Stand Up To Cancer awarded a $10 million grant to a research “dream team” that will strive to revolutionize the treatment of multiple myeloma through early detection of precursor conditions. “We tell people with precursor conditions that we will ‘watch and wait’ until it turns into multiple myeloma, with multiple tumors that can potentially cause...
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Multiple myeloma (MM) is the second most common hematologic malignancy and represents approximately 10% of all hematological neoplasms. Standard therapy consists of induction therapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) or, if ASCT cannot be performed, standard doublet, triplet, or quadruplet, novel agent–containing induction treatment until progression. Although MM is still...
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Greetings as the days get shorter. Thanks to all the people who turned out for our last Wellington seminar on February 21. Dr Rob Weinkove delivered a masterly talk on Car –T cell therapy which was very topical as clinical trials are likely to begin in Wellington by end of this year. The initial patients...
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Adaptive Biotechnologies is collaborating with Sanofi to use its clonoSEQ Assay for measuring minimal residual disease in multiple myeloma patients receiving isatuximab, a treatment candidate for newly diagnosed, relapsed or refractory multiple myeloma. Through this partnership, researchers will test clonoSEQ’s ability to both measure minimal residual disease (MRD) and determine the clinical value of monitoring MRD in isatuximab-treated patients. “MRD status is being...
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The addition of elotuzumab (Empliciti) to pomalidomide (Pomalyst) and dexamethasone cut the risk of disease progression or death by 46% compared with pomalidomide and dexamethasone alone for patients with relapsed/refractory multiple myeloma, according to findings from the phase II ELOQUENT-3 trial reported at the 2018 EHA Congress. Median progression-free survival (PFS) was 10.3 months (95%...
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Once weekly versus twice weekly carfilzomib dosing in patients with relapsed and refractory multiple myeloma (A.R.R.O.W.): interim analysis results of a randomised, phase 3 study Moreau, Mateos, Berenson, Weisel, Lazzaro, Song, Dimopoulos, Huang, Zahlten-Kumeli & Stewart. Lancet Oncol, June 2018.   Background Twice a week carfilzomib at 27 mg/m² is approved for treatment of relapsed or...
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Administering carfilzomib once a week significantly improves progression-free survival (PFS) and toxicity compared with twice a week among patients with relapsed/refractory multiple myeloma (RRMM), according to a study published in The Lancet Haematology.1 Carfilzomib twice weekly is currently approved for the treatment of RRMM but is associated with significant burden to both patients and caregivers as treatment...
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CHICAGO (Reuters) – Patients with advanced multiple myeloma treated with bluebird bio’s experimental immunotherapy lived for a median of nearly a year before their cancer worsened, according to data from a small study presented on Friday.   Nick Leschly, CEO of bluebird, speaks in Houston, Texas, U.S., April 10, 2018. REUTERS/Daniel Kramer The treatment, called...
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CHICAGO: Patients with advanced multiple myeloma treated with bluebird bio’s experimental immunotherapy lived for a median of nearly a year before their cancer worsened, according to data from a small study presented on Friday. The treatment, called bb2121, belongs to a hot new therapy class called CAR-T that harvests a patient’s own disease-fighting T-cells, genetically modifies them in...
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